Characterization of a Major Bacillus anthracis Spore Coat Protein and Its Role in Spore Inactivation
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چکیده
منابع مشابه
Characterization of a major Bacillus anthracis spore coat protein and its role in spore inactivation.
A major Bacillus anthracis spore coat protein of 13.4 kDa, designated Cot alpha, was found only in the Bacillus cereus group. A stable ca. 30-kDa dimer of this protein was also present in spore coat extracts. Cot alpha, which is encoded by a monocistronic gene, was first detected late in sporulation, consistent with a sigma(K)-regulated gene. On the basis of immunogold labeling, the protein is ...
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Bacterial spores are encased in a multilayered proteinaceous shell, called the coat. In many Bacillus spp., the coat protects against environmental assault and facilitates germination. In Bacillus anthracis, the spore is the etiological agent of anthrax, and the functions of the coat likely contribute to virulence. Here, we characterize a B. anthracis spore protein, called Cotbeta, which is enc...
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In response to starvation, bacilli and clostridia undergo a specialized program of development that results in the production of a highly resistant dormant cell type known as the spore. A proteinacious shell, called the coat, encases the spore and plays a major role in spore survival. The coat is composed of over 25 polypeptide species, organized into several morphologically distinct layers. Th...
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Spore coat proteins play an important role in maintaining spore structure as well as the resistive capacity of the spores. Spore morphogenetic proteins are responsible for layering the proteinaceous layers during spore morphogenesis. Previous studies have analyzed the dependence of certain coat proteins on the well-known morphogenetic proteins such as SpoIVA, CotE, CotH etc. Yet many coat prote...
متن کاملProcessing, assembly and localization of a Bacillus anthracis spore protein.
All Bacillus spores are encased in macromolecular shells. One of these is a proteinacious shell called the coat that, in Bacillus subtilis, provides critical protective functions. The Bacillus anthracis spore is the infectious particle for the disease anthrax. Therefore, the coat is of particular interest because it may provide essential protective functions required for the appearance of anthr...
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ژورنال
عنوان ژورنال: Journal of Bacteriology
سال: 2004
ISSN: 0021-9193,1098-5530
DOI: 10.1128/jb.186.8.2413-2417.2004